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Clonal dynamics studied in cultured induced pluripotent stem cells reveal major growth imbalances within a few weeks.

David Brenière-Letuffe | Aya Domke-Shibamiya | Arne Hansen | Thomas Eschenhagen | Boris Fehse | Kristoffer Riecken | Justus Stenzig
Stem cell research & therapy | 2018

Human induced pluripotent stem (iPS) cells have revolutionised research and spark hopes for future tissue replacement therapies. To obtain high cell numbers, iPS cells can be expanded indefinitely. However, as long-term expansion can compromise cell integrity and quality, we set out to assess potential reduction of clonal diversity by inherent growth imbalances.

Pubmed ID: 29914569

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K-562 (tool)

RRID:CVCL_0004

Cell line K-562 is a Cancer cell line with a species of origin Homo sapiens (Human)

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