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Ten weeks of high-intensity interval walk training is associated with reduced disease activity and improved innate immune function in older adults with rheumatoid arthritis: a pilot study.

David B Bartlett | Leslie H Willis | Cris A Slentz | Andrew Hoselton | Leslie Kelly | Janet L Huebner | Virginia B Kraus | Jennifer Moss | Michael J Muehlbauer | Guillaume Spielmann | William E Kraus | Janet M Lord | Kim M Huffman
Arthritis research & therapy | 2018

Rheumatoid arthritis (RA) is a chronic inflammatory disease in which adults have significant joint issues leading to poor health. Poor health is compounded by many factors, including exercise avoidance and increased risk of opportunistic infection. Exercise training can improve the health of patients with RA and potentially improve immune function; however, information on the effects of high-intensity interval training (HIIT) in RA is limited. We sought to determine whether 10 weeks of a walking-based HIIT program would be associated with health improvements as measured by disease activity and aerobic fitness. Further, we assessed whether HIIT was associated with improved immune function, specifically antimicrobial/bacterial functions of neutrophils and monocytes.

Pubmed ID: 29898765

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Associated grants

  • Agency: Medical Research Council, United Kingdom
    Id: MR/K00414X/1
  • Agency: Medical Research Council, United Kingdom
    Id: MR/P021220/1
  • Agency: NCATS NIH HHS, United States
    Id: UL1 TR001117

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Openlab (tool)

RRID:SCR_012158

A software package for performing 2D microscope image processing and integrating and controlling a diverse array of instrumentation in a laboratory environment. The software suite has four basic areas of operation acquisition, image presentation, and storage, analysis, and automation.

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