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Publication

Classical Risk Factors and Inflammatory Biomarkers: One of the Missing Biological Links between Cardiovascular Disease and Major Depressive Disorder.

Thomas C Baghai | Gabriella Varallo-Bedarida | Christoph Born | Sibylle Häfner | Cornelius Schüle | Daniela Eser | Peter Zill | André Manook | Johannes Weigl | Somayeh Jooyandeh | Caroline Nothdurfter | Clemens von Schacky | Brigitta Bondy | Rainer Rupprecht
International journal of molecular sciences | 2018

Cardiovascular disorders (CVD) and major depressive disorder (MDD) are the most frequent diseases worldwide responsible for premature death and disability. Behavioral and immunological variables influence the pathophysiology of both disorders. We therefore determined frequency and severity of MDD in CVD and studied whether MDD without CVD or other somatic diseases influences classical and inflammatory biomarkers of cardiovascular risk. In addition, we investigated the influence of proinflammatory cytokines on antidepressant treatment outcome.

Pubmed ID: 29895759

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