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Birthweight, Type 2 Diabetes Mellitus, and Cardiovascular Disease: Addressing the Barker Hypothesis With Mendelian Randomization.

Daniela Zanetti | Emmi Tikkanen | Stefan Gustafsson | James R Priest | Stephen Burgess | Erik Ingelsson
Circulation. Genomic and precision medicine | 2018

Low birthweight has been associated with a higher risk of hypertension, type 2 diabetes mellitus (T2D), and cardiovascular disease. The Barker hypothesis posits that intrauterine growth restriction resulting in lower birthweight is causal for these diseases, but causality is difficult to infer from observational studies.

Pubmed ID: 29875125

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Associated grants

  • Agency: Medical Research Council, United Kingdom
    Id: MC_PC_17228
  • Agency: Medical Research Council, United Kingdom
    Id: MR/L003120/1
  • Agency: British Heart Foundation, United Kingdom
    Id: RG/13/13/30194
  • Agency: Wellcome Trust, United Kingdom
    Id: 204623
  • Agency: Medical Research Council, United Kingdom
    Id: MC_UU_00002/7
  • Agency: Wellcome Trust, United Kingdom
    Id: 204623/Z/16/Z
  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK116074
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL135313
  • Agency: Medical Research Council, United Kingdom
    Id: MC_QA137853

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Magic (tool)

RRID:SCR_006406

Web based interface for exploring and analyzing a comprehensive maize-specific cross-platform expression compendium. This compendium was constructed by collecting, homogenizing and formally annotating publicly available microarrays from Gene Expression Omnibus (GEO), and ArrayExpress.

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DIAGRAM (tool)

RRID:SCR_015675

Consortium of researchers aiming to characterize the genetic basis of type 2 diabetes with a principal focus on samples of European descent. DIAGRAM also features a database of DIAGRAM publications and diabetes-related research data.

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