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Parthenolide attenuated bleomycin-induced pulmonary fibrosis via the NF-κB/Snail signaling pathway.

Xiao-He Li | Ting Xiao | Jia-Huan Yang | Yuan Qin | Jing-Jing Gao | Hui-Juan Liu | Hong-Gang Zhou
Respiratory research | 2018

Parthenolide (PTL) is a natural molecule isolated from Tanacetum parthenium that exhibits excellent anti-inflammatory and antitumor activities. Pulmonary fibrosis (PF), especially idiopathic pulmonary fibrosis (IPF), is a chronic lung disease that lacks a proven effective therapy. The present study evaluated the therapeutic effect of PTL on PF.

Pubmed ID: 29871641

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Associated grants

  • Agency: Tianjin science and technology innovation system and the condition of platform construction plan, International
    Id: 14TXSYJC00572
  • Agency: Innovation fund for technology based firms, International
    Id: 12ZXCXSY06500
  • Agency: Innovation fund for technology based firms, International
    Id: 12ZXCXSY07200
  • Agency: Open fund project of State Key Laboratory of Medicinal Chemical Biology, International
    Id: 2018128

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Gene Ontology (tool)

RRID:SCR_002811

Computable knowledge regarding functions of genes and gene products. GO resources include biomedical ontologies that cover molecular domains of all life forms as well as extensive compilations of gene product annotations to these ontologies that provide largely species-neutral, comprehensive statements about what gene products do. Used to standardize representation of gene and gene product attributes across species and databases.

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A-549 (tool)

RRID:CVCL_0023

Cell line A-549 is a Cancer cell line with a species of origin Homo sapiens (Human)

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HFF-1 (tool)

RRID:CVCL_3285

Cell line HFF-1 is a Finite cell line with a species of origin Homo sapiens (Human)

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