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Publication

IFI44L is a novel tumor suppressor in human hepatocellular carcinoma affecting cancer stemness, metastasis, and drug resistance via regulating met/Src signaling pathway.

Wei-Chieh Huang | Shiao-Lin Tung | Yao-Li Chen | Po-Ming Chen | Pei-Yi Chu
BMC cancer | 2018

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. The disease recurrent rate is relatively high resulted in poor 5-year survival in advanced HCC. Cancer stem cells (CSCs) have been considered to be one of the main mechanisms for chemoresistance, metastasis, and recurrent disease. Interferon-induced protein 44-like (IFI44L) gene is a type I interferon-stimulated gene (ISG) and belongs to the IFI44 family. Previous reports indicated antiviral activity against HCV in IFI44L, however, its precise role and function in HCC has not been unveiled.

Pubmed ID: 29848298

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Associated grants

  • Agency: Ministry of Science and Technology, Taiwan,
    Id: 103-2314-B-442-002-MY3
  • Agency: Ministry of Science and Technology, Taiwan,
    Id: 106-2314-B-442-001-MY3

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.

Hep 3B2.1-7 (tool)

RRID:CVCL_0326

Cell line Hep 3B2.1-7 is a Cancer cell line with a species of origin Homo sapiens (Human)

View all literature mentions

Hep-G2 (tool)

RRID:CVCL_0027

Cell line Hep-G2 is a Cancer cell line with a species of origin Homo sapiens (Human)

View all literature mentions

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