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Publication

Thrombin and factor Xa link the coagulation system with liver fibrosis.

Ameet Dhar | Fouzia Sadiq | Quentin M Anstee | Adam P Levene | Robert D Goldin | Mark R Thursz
BMC gastroenterology | 2018

Thrombin activates hepatic stellate cells via protease-activated receptor-1. The role of Factor Xa (FXa) in hepatic fibrosis has not been elucidated. We aimed to evaluate the impact of FXa and thrombin in vitro on stellate cells and their respective inhibition in vivo using a rodent model of hepatic fibrosis.

Pubmed ID: 29739329

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Associated grants

  • Agency: Medical Research Council, United Kingdom
    Id: G0701716

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