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Development of nanoemulsion for efficient brain parenteral delivery of cefuroxime: designs, characterizations, and pharmacokinetics.

Siti Norhawani Harun | Syafinaz Amin Nordin | Siti Salwa Abd Gani | Ahmad Fuad Shamsuddin | Mahiran Basri | Hamidon Bin Basri
International journal of nanomedicine | 2018

Drugs that are effective against diseases in the central nervous system and reach the brain via blood must pass through the blood-brain barrier (BBB), a unique interface that protects against potential harmful molecules. This presents a major challenge in neuro-drug delivery. This study attempts to fabricate the cefuroxime-loaded nanoemulsion (CLN) to increase drug penetration into the brain when parenterally administered.

Pubmed ID: 29731632

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SD (tool)

RRID:RGD_70508

Rattus norvegicus with name SD from RGD.

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