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PANcreatic-DERived factor (PANDER, FAM3B) is a novel hormone that regulates glucose levels via interaction with both the endocrine pancreas and liver. Prior studies examining PANDER were primarily conducted in murine models or in vitro but little is known regarding the circulating concentration of PANDER in humans, especially with regard to the association of type 2 diabetes (T2D) or overall glycemic regulation. To address this limitation, we performed a cross-sectional analysis of circulating serum PANDER concentration in association with other hormones that serve as either markers of insulin resistance (insulin and adiponectin) or to metabolic parameters of glycemic control such as fasting HbA1c and blood glucose (FBG).
Pubmed ID: 29686968
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A biomaterial supply resource containing over 600,000 samples of human tissue, serum, DNA, and RNA. Samples are handled consistently according to validated protocols and each tissue sample comes with detailed demographic information, gold standard clinical diagnostic information, complete drug history, full pathology reports, and complete phenotypic data.
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