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An immunoproteomic approach revealed antigenic proteins enhancing serodiagnosis performance of bird fancier's lung.

Adeline Rouzet | Gabriel Reboux | Jean-Charles Dalphin | Anne Gondouin | Paul De Vuyst | Thierry Balliau | Laurence Millon | Benoit Valot | Sandrine Roussel
Journal of immunological methods | 2017

Bird fancier's lung (BFL) caused by repeated inhalation of avian proteins is the most common form of hypersensitivity pneumonitis. However, the exact identification of proteins involved is unknown, and serological test use for diagnosis need to be standardized. The objectives of this study were (i) to identify antigenic proteins from pigeon droppings (ii) to provide information about their location in avian matrices and (iii) to produce them in recombinant proteins to evaluate their diagnostic performances.

Pubmed ID: 28760669

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Collection of data of protein sequence and functional information. Resource for protein sequence and annotation data. Consortium for preservation of the UniProt databases: UniProt Knowledgebase (UniProtKB), UniProt Reference Clusters (UniRef), and UniProt Archive (UniParc), UniProt Proteomes. Collaboration between European Bioinformatics Institute (EMBL-EBI), SIB Swiss Institute of Bioinformatics and Protein Information Resource. Swiss-Prot is a curated subset of UniProtKB.

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