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Glucagon supports glucose homeostasis by stimulating hepatic gluconeogenesis, in part by promoting the uptake and conversion of amino acids into gluconeogenic precursors. Genetic disruption or pharmacologic inhibition of glucagon signaling results in elevated plasma amino acids and compensatory glucagon hypersecretion involving expansion of pancreatic α cell mass. Recent findings indicate that hyperaminoacidemia triggers pancreatic α cell proliferation via an mTOR-dependent pathway. We confirm and extend these findings by demonstrating that glucagon pathway blockade selectively increases expression of the sodium-coupled neutral amino acid transporter Slc38a5 in a subset of highly proliferative α cells and that Slc38a5 controls the pancreatic response to glucagon pathway blockade; most notably, mice deficient in Slc38a5 exhibit markedly decreased α cell hyperplasia to glucagon pathway blockade-induced hyperaminoacidemia. These results show that Slc38a5 is a key component of the feedback circuit between glucagon receptor signaling in the liver and amino-acid-dependent regulation of pancreatic α cell mass in mice.
Pubmed ID: 28591637
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A commercial graphing software company that offers scientific software for statistical analyses, curve fitting and data analysis. It offers four programs: Prism, InStat, StatMate and QuickCalcs.
View all literature mentionsCenter that produces knockout mice and carries out high-throughput phenotyping of each line in order to determine function of every gene in mouse genome. These mice will be preserved in repositories and made available to scientific community representing valuable resource for basic scientific research as well as generating new models for human diseases.
View all literature mentionsThis unknown targets Sheep IgG (H+L)
View all literature mentionsThis unknown targets Human IgG (H+L)
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis polyclonal targets SLC38A5 / SNAT5 antibody
View all literature mentionsThis polyclonal targets Insulin
View all literature mentionsThis polyclonal targets Mouse IgG (H+L)
View all literature mentionsThis monoclonal targets Mouse LAMP1/CD107a MAb (Clone 747203)
View all literature mentionsThis unknown targets Goat IgG (H+L)
View all literature mentionsThis unknown targets Human IgG (H+L)
View all literature mentionsThis monoclonal targets Somatostatin antibody [8.F.258]
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets Mouse E-Cadherin Affinity Purified Ab
View all literature mentionsThis polyclonal targets Porcine pancreatic insulin
View all literature mentionsThis polyclonal targets Guinea pig
View all literature mentionsThis unknown targets Guinea Pig IgG (H+L)
View all literature mentionsThis monoclonal targets Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP Rabbit mAb
View all literature mentionsThis unknown targets
View all literature mentionsThis polyclonal targets Rabbit IgG
View all literature mentionsThis monoclonal targets Glucagon
View all literature mentionsThis polyclonal targets Somatostatin N-Terminal antibody produced in rabbit
View all literature mentionsThis polyclonal targets Ki-67/MKI67
View all literature mentionsThis polyclonal targets Ki-67/MKI67
View all literature mentionsThis polyclonal targets Pancreatic polypeptide/PPY antibody produced in goat
View all literature mentionsThis polyclonal targets goat IgG
View all literature mentionsThis unknown targets Human IgG (H+L)
View all literature mentionsCommercially available software for visualization and analysis of next generation sequencing data. Used for viewing, exploring, and sharing of NGS analysis results. Complete toolkit for genomics, transcriptomics, epigenomics, and metagenomics in one program.
View all literature mentionsCell line alphaTC1 Clone 6 is a Cancer cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsCell line alphaTC1 Clone 6 is a Cancer cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsThis monoclonal targets Mouse LAMP1/CD107a MAb (Clone 747203)
View all literature mentionsThis polyclonal targets SLC38A5 / SNAT5 antibody
View all literature mentionsThis unknown targets Goat IgG (H+L)
View all literature mentionsMus musculus with name C57BL/6NCrl from IMSR.
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis polyclonal targets Mouse IgG (H+L)
View all literature mentionsThis unknown targets Human IgG (H+L)
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsThis polyclonal targets Insulin
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE. Documented on August 30,2023. Software for differential gene expression analysis based on the negative binomial distribution. It estimates variance-mean dependence in count data from high-throughput sequencing assays and tests for differential expression.
View all literature mentionsThis monoclonal targets Somatostatin antibody [8.F.258]
View all literature mentionsThis monoclonal targets Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP Rabbit mAb
View all literature mentionsMus musculus with name Crl:CD1(ICR) from IMSR.
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsQuality control software that perform checks on raw sequence data coming from high throughput sequencing pipelines. This software also provides a modular set of analyses which can give a quick impression of the quality of the data prior to further analysis.
View all literature mentionsThis monoclonal targets Glucagon
View all literature mentionsThis monoclonal targets Somatostatin antibody [8.F.258]
View all literature mentionsThis polyclonal targets Mouse E-Cadherin Affinity Purified Ab
View all literature mentionsThis polyclonal targets Guinea pig
View all literature mentionsThis polyclonal targets Rabbit IgG
View all literature mentionsSoftware tool for fast and high throughput alignment of shotgun cDNA sequencing reads generated by transcriptomics technologies. Fast splice junction mapper for RNA-Seq reads. Aligns RNA-Seq reads to mammalian-sized genomes using ultra high-throughput short read aligner Bowtie, and then analyzes mapping results to identify splice junctions between exons.TopHat2 is accurate alignment of transcriptomes in presence of insertions, deletions and gene fusions.
View all literature mentionsThis unknown targets Human IgG (H+L)
View all literature mentionsThis polyclonal targets Porcine pancreatic insulin
View all literature mentionsThis unknown targets
View all literature mentionsThis unknown targets Sheep IgG (H+L)
View all literature mentionsThis unknown targets Guinea Pig IgG (H+L)
View all literature mentionsThis polyclonal targets Pancreatic polypeptide/PPY antibody produced in goat
View all literature mentionsThis polyclonal targets Somatostatin N-Terminal antibody produced in rabbit
View all literature mentionsThis polyclonal targets goat IgG
View all literature mentions