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Expansion of CD26 positive fibroblast population promotes keloid progression.

Yu Xin | Xiangsheng Wang | Ming Zhu | Miao Qu | Melia Bogari | Li Lin | Zin Mar Aung | Wei Chen | Xiaojun Chen | Gang Chai | Yan Zhang
Experimental cell research | 2017

Keloid is a skin fibrosis disease that characterised by invasive growth of fibroblasts and aberrant deposition of extracellular matrix. Studies indicated that keloid fibroblasts (KFs) is a class of 'activated' fibroblasts, which show accelerated proliferation and excessive extracellular matrix formation as compared with normal fibroblasts (NFs). However, the mechanism underlying keloid fibroblasts dysfunction is still unknown.

Pubmed ID: 28454879

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