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Publication

Synthetic lethality between PAXX and XLF in mammalian development.

Gabriel Balmus | Ana C Barros | Paul W G Wijnhoven | Chloé Lescale | Hélène Lenden Hasse | Katharina Boroviak | Carlos le Sage | Brendan Doe | Anneliese O Speak | Antonella Galli | Matt Jacobsen | Ludovic Deriano | David J Adams | Andrew N Blackford | Stephen P Jackson
Genes & development | 2016

PAXX was identified recently as a novel nonhomologous end-joining DNA repair factor in human cells. To characterize its physiological roles, we generated Paxx-deficient mice. Like Xlf-/- mice, Paxx-/- mice are viable, grow normally, and are fertile but show mild radiosensitivity. Strikingly, while Paxx loss is epistatic with Ku80, Lig4, and Atm deficiency, Paxx/Xlf double-knockout mice display embryonic lethality associated with genomic instability, cell death in the central nervous system, and an almost complete block in lymphogenesis, phenotypes that closely resemble those of Xrcc4-/- and Lig4-/- mice. Thus, combined loss of Paxx and Xlf is synthetic-lethal in mammals.

Pubmed ID: 27798842

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Associated grants

  • Agency: Wellcome Trust, United Kingdom
  • Agency: Cancer Research UK, United Kingdom
    Id: 13031
  • Agency: European Research Council, International
    Id: 310917

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B6;129S6-Lig4tm1Fwa/Kvm (tool)

RRID:IMSR_JAX:006482

Mus musculus with name B6;129S6-Lig4tm1Fwa/Kvm from IMSR.

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B6.129-Xrcc5tm1Nus/J (tool)

RRID:IMSR_JAX:004361

Mus musculus with name B6.129-Xrcc5tm1Nus/J from IMSR.

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