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Publication

Suppression of cytochrome p450 reductase enhances long-term hematopoietic stem cell repopulation efficiency in mice.

Yan Zhang | Fang Dong | Na Zhang | Hui Cheng | Yakun Pang | Xiaomin Wang | Jing Xu | Xinxin Ding | Tao Cheng | Jun Gu | Weiping Yuan
PloS one | 2013

Bone marrow microenvironment (niche) plays essential roles in the fate of hematopoietic stem cells (HSCs). Intracellular and extracellular redox metabolic microenvironment is one of the critical factors for the maintenance of the niche. Cytochrome P450 reductase (CPR) is an obligate electron donor to all microsomal cytochrome P450 enzymes (P450 or CYP), and contributes to the redox metabolic process. However, its role in maintaining HSCs is unknown.

Pubmed ID: 23922855

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C57BL/6J (tool)

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Mus musculus with name C57BL/6J from IMSR.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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