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S100A8 and S100A9 are associated with colorectal carcinoma progression and contribute to colorectal carcinoma cell survival and migration via Wnt/β-catenin pathway.

Liang Duan | Rui Wu | Liwei Ye | Haiyan Wang | Xia Yang | Yunyuan Zhang | Xian Chen | Guowei Zuo | Yan Zhang | Yaguang Weng | Jinyong Luo | Min Tang | Qiong Shi | Tongchuan He | Lan Zhou
PloS one | 2013

S100A8 and S100A9, two members of the S100 protein family, have been reported in association with the tumor cell differentiation and tumor progression. Previous study has showed that their expression in stromal cells of colorectal carcinoma (CRC) is associated with tumor size. Here, we investigated the clinical significances of S100A8 and S100A9 in tumor cells of CRC and their underlying molecular mechanisms.

Pubmed ID: 23637971

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