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Regulation of Kir4.1 expression in astrocytes and astrocytic tumors: a role for interleukin-1 β.

Emanuele Zurolo | Marjolein de Groot | Anand Iyer | Jasper Anink | Erwin A van Vliet | Jan J Heimans | Jaap C Reijneveld | Jan A Gorter | Eleonora Aronica
Journal of neuroinflammation | 2012

Decreased expression of inwardly rectifying potassium (Kir) channels in astrocytes and glioma cells may contribute to impaired K⁺ buffering and increased propensity for seizures. Here, we evaluated the potential effect of inflammatory molecules, such as interleukin-1β (IL-1β) on Kir4.1 mRNA and protein expression.

Pubmed ID: 23270518

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