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A microRNA network regulates proliferative timing and extracellular matrix synthesis during cellular quiescence in fibroblasts.

Eric J Suh | Matthew Y Remillard | Aster Legesse-Miller | Elizabeth L Johnson | Johanna M S Lemons | Talia R Chapman | Joshua J Forman | Mina Kojima | Eric S Silberman | Hilary A Coller
Genome biology | 2012

Although quiescence (reversible cell cycle arrest) is a key part in the life history and fate of many mammalian cell types, the mechanisms of gene regulation in quiescent cells are poorly understood. We sought to clarify the role of microRNAs as regulators of the cellular functions of quiescent human fibroblasts.

Pubmed ID: 23259597

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Associated grants

  • Agency: NIGMS NIH HHS, United States
    Id: P50 GM071508
  • Agency: NCI NIH HHS, United States
    Id: K01 CA128887
  • Agency: NHGRI NIH HHS, United States
    Id: T32 HG003284
  • Agency: NCI NIH HHS, United States
    Id: P30 CA072720
  • Agency: Howard Hughes Medical Institute, United States
  • Agency: NCI NIH HHS, United States
    Id: K01CA128887
  • Agency: NCI NIH HHS, United States
    Id: 5T32 CA009528
  • Agency: NIGMS NIH HHS, United States
    Id: 1R01 GM081686
  • Agency: NCI NIH HHS, United States
    Id: 2T32 CA009528
  • Agency: NIGMS NIH HHS, United States
    Id: 1R01 GM086465

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TargetScan (tool)

RRID:SCR_010845

Web tool to predict biological targets of miRNAs by searching for presence of conserved 8mer, 7mer and 6mer sites that match seed region of each miRNA. Nonconserved sites are also predicted and sites with mismatches in seed region that are compensated by conserved 3' pairing. Used to search for predicted microRNA targets in mammals.

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