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Genome analysis of a simultaneously predatory and prey-independent, novel Bdellovibrio bacteriovorus from the River Tiber, supports in silico predictions of both ancient and recent lateral gene transfer from diverse bacteria.

Laura Hobley | Thomas R Lerner | Laura E Williams | Carey Lambert | Rob Till | David S Milner | Sarah M Basford | Michael J Capeness | Andrew K Fenton | Robert J Atterbury | Maximilian A T S Harris | R Elizabeth Sockett
BMC genomics | 2012

Evolution equipped Bdellovibrio bacteriovorus predatory bacteria to invade other bacteria, digesting and replicating, sealed within them thus preventing nutrient-sharing with organisms in the surrounding environment. Bdellovibrio were previously described as "obligate predators" because only by mutations, often in gene bd0108, are 1 in ~1x10(7) of predatory lab strains of Bdellovibrio converted to prey-independent growth. A previous genomic analysis of B. bacteriovorus strain HD100 suggested that predatory consumption of prey DNA by lytic enzymes made Bdellovibrio less likely than other bacteria to acquire DNA by lateral gene transfer (LGT). However the Doolittle and Pan groups predicted, in silico, both ancient and recent lateral gene transfer into the B. bacteriovorus HD100 genome.

Pubmed ID: 23181807

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Associated grants

  • Agency: Biotechnology and Biological Sciences Research Council, United Kingdom
    Id: BB/G003092/1
  • Agency: Biotechnology and Biological Sciences Research Council, United Kingdom
    Id: BB/G013632/1
  • Agency: Biotechnology and Biological Sciences Research Council, United Kingdom
    Id: G003092/1
  • Agency: Biotechnology and Biological Sciences Research Council, United Kingdom
    Id: G01362/1

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PAML (tool)

RRID:SCR_014932

Package of programs for phylogenetic analyses of DNA or protein sequences using maximum likelihood. PAML estimates parameters and tests hypotheses to study the evolutionary process from a phylogenetic tree.

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