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Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt.

Selena Z Kuo | Katherine J Blair | Elham Rahimy | Alan Kiang | Eric Abhold | Jian-Bing Fan | Jessica Wang-Rodriguez | Xabier Altuna | Weg M Ongkeko
BMC cancer | 2012

Cancer stem cells (CSC) are believed to play a crucial role in cancer recurrence due to their resistance to conventional chemotherapy and capacity for self-renewal. Recent studies have reported that salinomycin, a livestock antibiotic, selectively targets breast cancer stem cells 100-fold more effectively than paclitaxel. In our study we sought to determine the effects of salinomycin on head and neck squamous cell carcinoma (HNSCC) stem cells.

Pubmed ID: 23176396

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