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Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies were observed in Alzheimer's patients and transgenic models at early ages. These axonal dystrophies could reflect the disruption of axonal transport and the accumulation of multiple vesicles at local points. It has been also proposed that dystrophies might interfere with normal intracellular proteolysis. In this work, we have investigated the progression of the hippocampal pathology and the possible implication in Abeta production in young (6 months) and aged (18 months) PS1(M146L)/APP(751sl) transgenic mice.
Pubmed ID: 23173743
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THIS RESOURCE IS NO LONGER IN SERVICE, documented on May 18, 2018; A software which provides unbiased stereological estimates of numbers, lengths, areas, and volumes present in images that were captured by microscopes or virtual slides. This software is intended to estimate structural information in a 3D format from 2D tissue sections.
There are other software tools at this company, but they have either changed names or are simply different software tools.
