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VEGF directly suppresses activation of T cells from ascites secondary to ovarian cancer via VEGF receptor type 2.

N G Gavalas | M Tsiatas | O Tsitsilonis | E Politi | K Ioannou | A C Ziogas | A Rodolakis | G Vlahos | N Thomakos | D Haidopoulos | E Terpos | A Antsaklis | M A Dimopoulos | A Bamias
British journal of cancer | 2012

Vascular endothelial growth factor action in tumour angiogenesis is well characterised; nevertheless, it functions as a key element in the promotion of the immune system's evasion by tumours. We sought to investigate the possible direct effect of VEGF on T-cell activation and through which type of VEGF receptor it exerts this effect on cells isolated from ovarian cancer patients' ascites.

Pubmed ID: 23169339

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K-562 (tool)

RRID:CVCL_0004

Cell line K-562 is a Cancer cell line with a species of origin Homo sapiens (Human)

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