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Publication

ERK1/2 and p38 MAPKs are complementarily involved in estradiol 17ß-D-glucuronide-induced cholestasis: crosstalk with cPKC and PI3K.

Andrea C Boaglio | Andrés E Zucchetti | Flavia D Toledo | Ismael R Barosso | Enrique J Sánchez Pozzi | Fernando A Crocenzi | Marcelo G Roma
PloS one | 2012

The endogenous, cholestatic metabolite estradiol 17ß-D-glucuronide (E(2)17G) induces endocytic internalization of the canalicular transporters relevant to bile formation, Bsep and Mrp2. We evaluated here whether MAPKs are involved in this effect.

Pubmed ID: 23166621

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WI (tool)

RRID:RGD_13508588

Rattus norvegicus with name WI from RGD.

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