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Generation and characterization of a defective HIV-1 Virus as an immunogen for a therapeutic vaccine.

Carmen Álvarez-Fernández | Alberto Crespo Guardo | Javier García-Pérez | Felipe García | Julia Blanco | Laura Escribà-García | Jose Maria Gatell | Jose Alcamí | Montserrat Plana | Sonsoles Sánchez-Palomino
PloS one | 2012

The generation of new immunogens able to elicit strong specific immune responses remains a major challenge in the attempts to obtain a prophylactic or therapeutic vaccine against HIV/AIDS. We designed and constructed a defective recombinant virus based on the HIV-1 genome generating infective but non-replicative virions able to elicit broad and strong cellular immune responses in HIV-1 seropositive individuals.

Pubmed ID: 23144996

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