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Publication

Activation of haem-oxidized soluble guanylyl cyclase with BAY 60-2770 in human platelets lead to overstimulation of the cyclic GMP signaling pathway.

Camila B Mendes-Silverio | Luiz O S Leiria | Rafael P Morganti | Gabriel F Anhê | Sisi Marcondes | Fabíola Z Mónica | Gilberto De Nucci | Edson Antunes
PloS one | 2012

Nitric oxide-independent soluble guanylyl cyclase (sGC) activators reactivate the haem-oxidized enzyme in vascular diseases. This study was undertaken to investigate the anti-platelet mechanisms of the haem-independent sGC activator BAY 60-2770 in human washed platelets. The hypothesis that sGC oxidation potentiates the anti-platelet activities of BAY 60-2770 has been tested.

Pubmed ID: 23144808

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