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Modeling 18F-FDG kinetics during acute lung injury: experimental data and estimation errors.

A Susanne Dittrich | Tilo Winkler | Tyler Wellman | Nicolas de Prost | Guido Musch | R Scott Harris | Marcos F Vidal Melo
PloS one | 2012

There is increasing interest in Positron Emission Tomography (PET) of 2-deoxy-2-[18F]flouro-D-glucose ((18)F-FDG) to evaluate pulmonary inflammation during acute lung injury (ALI). We assessed the effect of extra-vascular lung water on estimates of (18)F-FDG-kinetics parameters in experimental and simulated data using the Patlak and Sokoloff methods, and our recently proposed four-compartment model.

Pubmed ID: 23118881

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Associated grants

  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL086827
  • Agency: NHLBI NIH HHS, United States
    Id: 5R01HL086827

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RRID:SCR_013406

Organization which manufactures bacteria for research and clinical investigations. List Biological Laboratories cultivates native and recombinant microorganisms and purifies, formulates, and lyopholizes enzyme products, virulence factors, and microbial cell wall components. Products include antibodies, microbial toxins, peptides, and virulence factors. Services include live biotherapeutics for clinical trials, contracting research capabilities, GMP regulatory support, lyopholization services and support, and toxin compliance.

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