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Publication

Single liver lobe repopulation with wildtype hepatocytes using regional hepatic irradiation cures jaundice in Gunn rats.

Hongchao Zhou | Xinyuan Dong | Rafi Kabarriti | Yong Chen | Yesim Avsar | Xia Wang | Jianqiang Ding | Laibin Liu | Ira J Fox | Jayanta Roy-Chowdhury | Namita Roy-Chowdhury | Chandan Guha
PloS one | 2012

Preparative hepatic irradiation (HIR), together with mitotic stimulation of hepatocytes, permits extensive hepatic repopulation by transplanted hepatocytes in rats and mice. However, whole liver HIR is associated with radiation-induced liver disease (RILD), which limits its potential therapeutic application. In clinical experience, restricting HIR to a fraction of the liver reduces the susceptibility to RILD. Here we test the hypothesis that repopulation of selected liver lobes by regional HIR should be sufficient to correct some inherited metabolic disorders.

Pubmed ID: 23091601

Research resources used in this publication

None found

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Associated grants

  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK046057
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK064670
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK 67440
  • Agency: NCI NIH HHS, United States
    Id: R21 CA121051
  • Agency: NCI NIH HHS, United States
    Id: R33 CA121051
  • Agency: NIDDK NIH HHS, United States
    Id: DK RO1 079017
  • Agency: NCI NIH HHS, United States
    Id: R21/R33 CA121051
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK 46057
  • Agency: NCI NIH HHS, United States
    Id: CO24346
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK64670
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK067440

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F344 (tool)

RRID:RGD_60994

Rattus norvegicus with name F344 from RGD.

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