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Are there neurophenotypes for asthma? Functional brain imaging of the interaction between emotion and inflammation in asthma.

Melissa A Rosenkranz | William W Busse | John F Sheridan | Gina M Crisafi | Richard J Davidson
PloS one | 2012

Asthma is a chronic inflammatory disease noteworthy for its vulnerability to stress and emotion-induced symptom intensification. The fact that psychological stress and mood and anxiety disorders appear to increase expression of asthma symptoms suggests that neural signaling between the brain and lung at least partially modulates the inflammatory response and lung function. However, the precise nature of the neural pathways implicated in modulating asthma symptoms is unknown. Moreover, the extent to which variations in neural signaling predict different phenotypes of disease expression has not been studied.

Pubmed ID: 22870208

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Associated grants

  • Agency: NICHD NIH HHS, United States
    Id: P30 HD003352
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL069116
  • Agency: NIMH NIH HHS, United States
    Id: R01 MH043454
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL69116
  • Agency: NCRR NIH HHS, United States
    Id: P20 RR0202645

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Analysis of Functional NeuroImages (tool)

RRID:SCR_005927

Set of (mostly) C programs that run on X11+Unix-based platforms (Linux, Mac OS X, Solaris, etc.) for processing, analyzing, and displaying functional MRI (FMRI) data defined over 3D volumes and over 2D cortical surface meshes. AFNI is freely distributed as source code plus some precompiled binaries.

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METH (tool)

RRID:SCR_016104

Software toolkit of MATLAB functions that conduct data analysis of MEG and EEG data. It performs tasks such as EEG and MEG forward calculations, inverse calculations, power and coupling measures, decomposition, statistics, and visualization.

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