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The likelihood for immunological rejection of Human Leukocyte Antigens (HLA)-mismatched induced pluripotent stem cells (iPSCs) limits their therapeutic potential. Here we show how a tissue bank from 150 selected homozygous HLA-typed volunteers could match 93% of the UK population with a minimal requirement for immunosuppression. Our model provides a practical approach for using existing HLA-typed samples to generate an iPSC stem cell bank that circumvents prospective typing of a large number of individuals.
Pubmed ID: 22862941
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Bone Marrow Donors Worldwide (BMDW) is the continuing effort to collect the HLA phenotypes of volunteer stem cell donors and cord blood units, and is responsible for the co-ordination of their worldwide distribution. Participants are 63 stem cell donor registries from 44 countries, and 43 cord blood banks from 25 countries. The current number of donors and cord blood units in the BMDW database is: 14,605,618 (14,178,976 donors and 426,642 CBU''s The original goal to collect the HLA phenotypes of volunteer stem cell donors and cord blood units, and to co-ordinate their world-wide distribution remain their primary goals. But new initiatives have been added: - To maximise the chance of finding a stem cell donor or cord blood unit by providing access to all stem cell donors and cord blood units available in the world. - To minimise the effort required for stem cell donor or cord blood unit searches: only registries with potential stem cell donors or cord blood units need to be contacted. - To provide an estimate of the chance of finding a stem cell donor or cord blood unit for a given patient. - To provide advanced search programs to identify partially matched stem cell donors or cord blood units. - To facilitate search advice requests via the Internet. - To facilitate improvements in family search strategies. - To provide relevant general information for the benefit of the patient. - To provide statistics on the increase of different registries, the number of DNA typed donors, etc. Sponsors: Bone Marrow Donors Worldwide is an initiative of the Immunobiology Working Party of the European Group of Blood and Marrow Transplantation (EBMT) in 1988. Keyworss: Bone marrow, Donor, Cell, Phenotype, Stem cell, Cord blood unit,
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