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Publication

Generation of a selectively cytotoxic fusion protein against p53 mutated cancers.

Christina A Kousparou | Efthymia Yiacoumi | Mahendra P Deonarain | Agamemnon A Epenetos
BMC cancer | 2012

A significant number of cancers are caused by defects in p21 causing functional defects in p21 or p53 tumour-suppressor proteins. This has led to many therapeutic approaches including restoration by gene therapy with wild-type p53 or p21 using viral or liposomal vectors, which have toxicity or side-effect limitations. We set out to develop a safer, novel fusion protein which has the ability to reconstitute cancer cell lines with active p21 by protein transduction.

Pubmed ID: 22862878

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SK-OV-3 (tool)

RRID:CVCL_0532

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BALB/cAnNCrl (tool)

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HCT 116 (tool)

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SK-OV-3 (tool)

RRID:CVCL_0532

Cell line SK-OV-3 is a Cancer cell line with a species of origin Homo sapiens (Human)

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