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Publication

Activation of indoleamine 2,3-dioxygenase in patients with scrub typhus and its role in growth restriction of Orientia tsutsugamushi.

Thanavadee Prachason | Kanittha Konhan | Piyapat Pongnarin | Somruedee Chatsiricharoenkul | Yupin Suputtamongkol | Chanin Limwongse
PLoS neglected tropical diseases | 2012

Our earlier genome-wide expression study revealed up-regulation of a tryptophan-catabolizing enzyme, indoleamine 2,3-dioxygenase (IDO1), in patients with scrub typhus. This gene has been previously reported to have anti-microbial activity in a variety of infectious diseases; therefore, we aimed to prove whether it is also involved in host defense against Orientia tsutsugamushi (OT) infection.

Pubmed ID: 22860140

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