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Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples.

Nicola Segata | Susan Kinder Haake | Peter Mannon | Katherine P Lemon | Levi Waldron | Dirk Gevers | Curtis Huttenhower | Jacques Izard
Genome biology | 2012

To understand the relationship between our bacterial microbiome and health, it is essential to define the microbiome in the absence of disease. The digestive tract includes diverse habitats and hosts the human body's greatest bacterial density. We describe the bacterial community composition of ten digestive tract sites from more than 200 normal adults enrolled in the Human Microbiome Project, and metagenomically determined metabolic potentials of four representative sites.

Pubmed ID: 22698087

Research resources used in this publication

None found

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Associated grants

  • Agency: NHGRI NIH HHS, United States
    Id: HG004969
  • Agency: NIDCR NIH HHS, United States
    Id: DE020751
  • Agency: NHGRI NIH HHS, United States
    Id: HG005969
  • Agency: NCI NIH HHS, United States
    Id: CA139193
  • Agency: NIDCR NIH HHS, United States
    Id: DE020298
  • Agency: NIDCR NIH HHS, United States
    Id: DE021574

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THIS RESOURCE IS NO LONGER IN SERVICE. Documented on February 28,2023. Algorithm for high-dimensional biomarker discovery and explanation that identifies genes, pathways, or taxa characterizing the differences between two or more biological conditions. The algorithm identifies features that are statistically different among biological classes, then performs additional tests to assess whether these differences are consistent with respect to expected biological behavior. Statistical significance and biological relevance are emphasized.

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