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Publication

B-cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle-like cells in the skin.

Dimitrios Daoussis | Athanassios C Tsamandas | Stamatis-Nick C Liossis | Ioannis Antonopoulos | Elli Karatza | Georgios Yiannopoulos | Andrew P Andonopoulos
Arthritis research & therapy | 2012

Recently, several studies assessing the clinical efficacy of rituximab (RTX) in systemic sclerosis (SSc) have reported encouraging results. We aimed at exploring whether RTX exerts its beneficial effects on fibrosis through attenuation of platelet-derived growth factor receptor (PDGFR) pathway activation.

Pubmed ID: 22697462

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RRID:SCR_007369

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 18,2023. Software package to capture, process, measure, analyze and share images and data.

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