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Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast cancer cells.

Lacey M Litchfield | Krista A Riggs | Alyson M Hockenberry | Laura D Oliver | Katelyn G Barnhart | Jian Cai | William M Pierce | Margarita M Ivanova | Paula J Bates | Savitri N Appana | Susmita Datta | Piotr Kulesza | Jean McBryan | Leonie S Young | Carolyn M Klinge
PloS one | 2012

The orphan nuclear receptor COUP-TFII plays an undefined role in breast cancer. Previously we reported lower COUP-TFII expression in tamoxifen/endocrine-resistant versus sensitive breast cancer cell lines. The identification of COUP-TFII-interacting proteins will help to elucidate its mechanism of action as a transcriptional regulator in breast cancer.

Pubmed ID: 22693611

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Associated grants

  • Agency: NIEHS NIH HHS, United States
    Id: T32 ES011564

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