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Altered adipocyte progenitor population and adipose-related gene profile in adipose tissue by long-term high-fat diet in mice.

Xiaohua Xu | Cuiqing Liu | Zhaobin Xu | Kevin Tzan | Aixia Wang | Sanjay Rajagopalan | Qinghua Sun
Life sciences | 2012

High-fat diet (HFD) is associated with adipose inflammation, which contributes to key components of metabolic abnormalities. The expanded adipose tissue mass associated with obesity is the result of hyperplasia and hypertrophy of adipocytes. In this study, we investigated the effects of long-term HFD on adipocyte progenitor cell (APC) population and adipose-specific gene profiles in both white and brown adipose, and the role of perivascular adipose in the alteration of vascular function in response to HFD.

Pubmed ID: 22683431

Research resources used in this publication

None found

Antibodies used in this publication

None found

Associated grants

  • Agency: NIEHS NIH HHS, United States
    Id: R56 ES018900
  • Agency: NIEHS NIH HHS, United States
    Id: ES017412
  • Agency: NIEHS NIH HHS, United States
    Id: ES015146
  • Agency: NIEHS NIH HHS, United States
    Id: R21 ES017412
  • Agency: NIEHS NIH HHS, United States
    Id: R01 ES015146
  • Agency: NIEHS NIH HHS, United States
    Id: ES016588
  • Agency: NIEHS NIH HHS, United States
    Id: K01 ES016588
  • Agency: NIEHS NIH HHS, United States
    Id: R01 ES018900
  • Agency: NIEHS NIH HHS, United States
    Id: ES018900

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