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Publication

Retinoic acid and liver X receptor agonist synergistically inhibit HIV infection in CD4+ T cells by up-regulating ABCA1-mediated cholesterol efflux.

Hong Jiang | Yunden Badralmaa | Jun Yang | Richard Lempicki | Allison Hazen | Ven Natarajan
Lipids in health and disease | 2012

Retinoic acids regulate the reverse cholesterol transport by inducing the ATP binding cassette transporter A1 (ABCA1) dependent cholesterol efflux in macrophages, neuronal as well as intestine cells. In the present study, we aim to test the effect of all trans retinoic acid (ATRA) on ABCA1 expression in human CD4+ T cells and the involvement of cholesterol in ATRA mediated anti-HIV effect.

Pubmed ID: 22676378

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Associated grants

  • Agency: PHS HHS, United States
    Id: HHSN261200800001E

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