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Dihydroartemisinin enhances Apo2L/TRAIL-mediated apoptosis in pancreatic cancer cells via ROS-mediated up-regulation of death receptor 5.

Rui Kong | Guang Jia | Zhuo-xin Cheng | Yong-wei Wang | Ming Mu | Shuang-jia Wang | Shang-ha Pan | Yue Gao | Hong-chi Jiang | De-li Dong | Bei Sun
PloS one | 2012

Dihydroartemisinin (DHA), a semi-synthetic derivative of artemisinin, has recently shown antitumor activity in various cancer cells. Apo2 ligand or tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) is regarded as a promising anticancer agent, but chemoresistance affects its efficacy as a treatment strategy. Apoptosis induced by the combination of DHA and Apo2L/TRAIL has not been well documented, and the mechanisms involved remain unclear.

Pubmed ID: 22666346

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This is a list of tools and resources that we have found mentioned in this publication.


BxPC-3 (tool)

RRID:CVCL_0186

Cell line BxPC-3 is a Cancer cell line with a species of origin Homo sapiens (Human)

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PANC-1 (tool)

RRID:CVCL_0480

Cell line PANC-1 is a Cancer cell line with a species of origin Homo sapiens (Human)

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