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Publication

Telmisartan directly ameliorates the neuronal inflammatory response to IL-1β partly through the JNK/c-Jun and NADPH oxidase pathways.

Tao Pang | Juan Wang | Julius Benicky | Enrique Sánchez-Lemus | Juan M Saavedra
Journal of neuroinflammation | 2012

Blockade of angiotensin II type 1 (AT1) receptors ameliorates brain inflammation, and reduces excessive brain interleukin-1 beta (IL-1β) production and release from cortical microglia. The aim of this study was to determine whether, in addition, AT1 receptor blockade directly attenuates IL-1β-induced inflammatory responses in neuronal cultures.

Pubmed ID: 22642771

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Associated grants

  • Agency: Intramural NIH HHS, United States
    Id: Z99 MH999999

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