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Mechanism of the sex difference in neuronal ischemic cell death.

S L Fairbanks | J M Young | J W Nelson | C M Davis | I P Koerner | N J Alkayed
Neuroscience | 2012

Stroke risk and outcome are different in men and women. We hypothesized that this is partly due to an inherent difference in susceptibility to ischemia between neurons from male vs. female brains. We tested whether neurons from male rodents are more susceptible to in-vitro ischemia than cells from females, and if this is related to increased expression of soluble epoxide hydrolase (sEH). sEH contributes to neuronal cell death by inactivating neuroprotective epoxyeicosatrienoic acids (EETs).

Pubmed ID: 22641086

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Associated grants

  • Agency: NINDS NIH HHS, United States
    Id: NS070837
  • Agency: NINDS NIH HHS, United States
    Id: R01 NS044313
  • Agency: NHLBI NIH HHS, United States
    Id: T32 HL094294
  • Agency: NIGMS NIH HHS, United States
    Id: T32 GM082770
  • Agency: NINDS NIH HHS, United States
    Id: P30 NS061800
  • Agency: NINDS NIH HHS, United States
    Id: R01 NS070837
  • Agency: NIGMS NIH HHS, United States
    Id: T32 GM082770-03

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Imaris (tool)

RRID:SCR_007370

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Primer Express (tool)

RRID:SCR_014326

Software that allows users to manually or automatically design custom primers and probes for gene quantitation and allelic discrimination (SNP) real-time PCR applications. It supports assays based on TaqMan and SYBR Green I dye chemistries.

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