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Publication

CD44 enhances invasion of basal-like breast cancer cells by upregulating serine protease and collagen-degrading enzymatic expression and activity.

Nicola Montgomery | Ashleigh Hill | Suzanne McFarlane | Jessica Neisen | Anthony O'Grady | Susie Conlon | Karin Jirstrom | Elaine W Kay | David J J Waugh
Breast cancer research : BCR | 2012

Basal-like breast cancers (BL-BCa) have the worst prognosis of all subgroups of this disease. Hyaluronan (HA) and the HA receptor CD44 have a long-standing association with cell invasion and metastasis of breast cancer. The purpose of this study was to establish the relation of CD44 to BL-BCa and to characterize how HA/CD44 signaling promotes a protease-dependent invasion of breast cancer (BrCa) cells.

Pubmed ID: 22621373

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Associated grants

  • Agency: Breast Cancer Now, United Kingdom
    Id: 2003:738

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

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