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Toll-like receptor 4 knockout protects against anthrax lethal toxin-induced cardiac contractile dysfunction: role of autophagy.

Machender R Kandadi | Arthur E Frankel | Jun Ren
British journal of pharmacology | 2012

Anthrax lethal toxin (LeTx) is known to induce circulatory shock and death, although the underlying mechanisms have not been elucidated. This study was designed to evaluate the role of toll-like receptor 4 (TLR4) in anthrax lethal toxin-induced cardiac contractile dysfunction.

Pubmed ID: 22612289

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Associated grants

  • Agency: NCRR NIH HHS, United States
    Id: P20 RR016474
  • Agency: NCRR NIH HHS, United States
    Id: P20 RR16474

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SMART (tool)

RRID:SCR_005026

Software tool for identification and annotation of genetically mobile domains and analysis of domain architectures.

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