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Publication

Runx2 mediates epigenetic silencing of the bone morphogenetic protein-3B (BMP-3B/GDF10) in lung cancer cells.

Manish Tandon | Karthiga Gokul | Syed A Ali | Zujian Chen | Jane Lian | Gary S Stein | Jitesh Pratap
Molecular cancer | 2012

The Runt-related transcription factor Runx2 is essential for bone development but is also implicated in progression of several cancers of breast, prostate and bone, where it activates cancer-related genes and promotes invasive properties. The transforming growth factor β (TGF-β) family member bone morphogenetic protein-3B (BMP-3B/GDF10) is regarded as a tumor growth inhibitor and a gene silenced in lung cancers; however the regulatory mechanisms leading to its silencing have not been identified.

Pubmed ID: 22537242

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: P01 CA082834
  • Agency: NCI NIH HHS, United States
    Id: P30 CA147881
  • Agency: NCI NIH HHS, United States
    Id: 5 R03 CA123599-02

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NCI-H1299 (tool)

RRID:CVCL_0060

Cell line NCI-H1299 is a Cancer cell line with a species of origin Homo sapiens (Human)

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WI-38 (tool)

RRID:CVCL_0579

Cell line WI-38 is a Finite cell line with a species of origin Homo sapiens

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