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Glycogen synthase kinase-3β, NF-κB signaling, and tumorigenesis of human osteosarcoma.

Qing-Lian Tang | Xian-Biao Xie | Jin Wang | Qiong Chen | An-Jia Han | Chang-Ye Zou | Jun-Qiang Yin | Da-Wei Liu | Yi Liang | Zhi-Qiang Zhao | Bi-Cheng Yong | Ru-Hua Zhang | Qi-Sheng Feng | Wu-Guo Deng | Xiao-Feng Zhu | Binhua P Zhou | Yi-Xin Zeng | Jing-Nan Shen | Tiebang Kang
Journal of the National Cancer Institute | 2012

Glycogen synthase kinase-3β (GSK-3β), a serine/threonine protein kinase, may function as a tumor suppressor or an oncogene, depending on the tumor type. We sought to determine the biological function of GSK-3β in osteosarcoma, a rare pediatric cancer for which the identification of new therapeutic targets is urgent.

Pubmed ID: 22534782

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U2OS (tool)

RRID:CVCL_0042

Cell line U2OS is a Cancer cell line with a species of origin Homo sapiens (Human)

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NU/J (tool)

RRID:IMSR_JAX:002019

Mus musculus with name NU/J from IMSR.

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