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Publication

Early vascular deficits are correlated with delayed mammary tumorigenesis in the MMTV-PyMT transgenic mouse following genetic ablation of the NG2 proteoglycan.

Krissa Gibby | Weon-Kyoo You | Kuniko Kadoya | Hildur Helgadottir | Lawrence Jt Young | Lesley G Ellies | Yunchao Chang | Robert D Cardiff | William B Stallcup
Breast cancer research : BCR | 2012

The neuron-glial antigen 2 (NG2) proteoglycan promotes pericyte recruitment and mediates pericyte interaction with endothelial cells. In the absence of NG2, blood vessel development is negatively impacted in several pathological models. Our goal in this study was to determine the effect of NG2 ablation on the early development and function of blood vessels in mammary tumors in the mammary tumor virus-driven polyoma middle T (MMTV-PyMT) transgenic mouse, and to correlate these vascular changes with alterations in mammary tumor growth.

Pubmed ID: 22531600

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: R01 CA095287
  • Agency: NICHD NIH HHS, United States
    Id: P01 HD25938
  • Agency: NCI NIH HHS, United States
    Id: K08 CA88035
  • Agency: NCI NIH HHS, United States
    Id: 5T32 CA121949-04

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