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Publication

Thailandepsins are new small molecule class I HDAC inhibitors with potent cytotoxic activity in ovarian cancer cells: a preclinical study of epigenetic ovarian cancer therapy.

Andrew J Wilson | Yi-Qiang Cheng | Dineo Khabele
Journal of ovarian research | 2012

New treatment strategies are emerging to target DNA damage response pathways in ovarian cancer. Our group has previously shown that the class I biased HDAC inhibitor romidepsin (FK228) induces DNA damage response and has potent cytotoxic effects in ovarian cancer cells. Here, we investigated newly discovered HDAC inhibitors, thailandepsin A (TDP-A) and thailandepsin B (TDP-B), to determine the effects on cell viability, apoptosis and DNA damage response in ovarian cancer cells.

Pubmed ID: 22531354

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: K08 CA148887
  • Agency: NCI NIH HHS, United States
    Id: R01 CA152212

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

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SK-OV-3 (tool)

RRID:CVCL_0532

Cell line SK-OV-3 is a Cancer cell line with a species of origin Homo sapiens (Human)

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OVCAR-8 (tool)

RRID:CVCL_1629

Cell line OVCAR-8 is a Cancer cell line with a species of origin Homo sapiens (Human)

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SK-OV-3 (tool)

RRID:CVCL_0532

Cell line SK-OV-3 is a Cancer cell line with a species of origin Homo sapiens (Human)

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