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Genome-wide analysis of Pax8 binding provides new insights into thyroid functions.

Sergio Ruiz-Llorente | Enrique Carrillo Santa de Pau | Ana Sastre-Perona | Cristina Montero-Conde | Gonzalo Gómez-López | James A Fagin | Alfonso Valencia | David G Pisano | Pilar Santisteban
BMC genomics | 2012

The transcription factor Pax8 is essential for the differentiation of thyroid cells. However, there are few data on genes transcriptionally regulated by Pax8 other than thyroid-related genes. To better understand the role of Pax8 in the biology of thyroid cells, we obtained transcriptional profiles of Pax8-silenced PCCl3 thyroid cells using whole genome expression arrays and integrated these signals with global cis-regulatory sequencing studies performed by ChIP-Seq analysis

Pubmed ID: 22531031

Research resources used in this publication

None found

Antibodies used in this publication

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: P30 CA008748
  • Agency: NCI NIH HHS, United States
    Id: R01 CA050706

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