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Comparative transcriptional network modeling of three PPAR-α/γ co-agonists reveals distinct metabolic gene signatures in primary human hepatocytes.

Renée Deehan | Pia Maerz-Weiss | Natalie L Catlett | Guido Steiner | Ben Wong | Matthew B Wright | Gil Blander | Keith O Elliston | William Ladd | Maria Bobadilla | Jacques Mizrahi | Carolina Haefliger | Alan Edgar
PloS one | 2012

To compare the molecular and biologic signatures of a balanced dual peroxisome proliferator-activated receptor (PPAR)-α/γ agonist, aleglitazar, with tesaglitazar (a dual PPAR-α/γ agonist) or a combination of pioglitazone (Pio; PPAR-γ agonist) and fenofibrate (Feno; PPAR-α agonist) in human hepatocytes.

Pubmed ID: 22514701

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