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Antagonist-mediated down-regulation of Toll-like receptors increases the prevalence of human papillomavirus infection in systemic lupus erythematosus.

Shui-Lian Yu | Paul K S Chan | Chun-Kwok Wong | Cheuk-Chun Szeto | Suzanne C Ho | Karine So | May M Y Yu | So-Fan Yim | Tak-Hong Cheung | Martin C S Wong | Jo L K Cheung | Apple C M Yeung | Edmund K Li | Lai-Shan Tam
Arthritis research & therapy | 2012

Prevalence of an abnormal Papanicolaou smear was significantly increased in lupus patients in cross-sectional studies, associated with a higher prevalence of high-risk human papillomavirus (HPV) infection. The nucleic acid-specific Toll-like receptors (TLRs) locate at the endolysosomal compartments and trigger the induction of cytokines for the innate immune response. This study evaluated whether abnormal host innate immune response in lupus patients may enhance HPV persistence.

Pubmed ID: 22513098

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