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Despite decades of intense research efforts, actions of acute opioids are not fully understood. Increasing evidence suggests that in addition to well-documented antinociceptive effects opioids also produce paradoxical hyperalgesic and excitatory effects on neurons. However, most studies focus on the pronociceptive actions of chronic opioid exposure. Matrix metalloproteinase 9 (MMP-9) plays an important role in neuroinflammation and neuropathic pain development. We examined MMP-9 expression and localization in dorsal root ganglia (DRGs) after acute morphine treatment and, furthermore, the role of MMP-9 in modulating acute morphine-induced analgesia and hyperalgesia in mice.
Pubmed ID: 22444868
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Institution of higher education in the United States. Private Ivy League research university in Cambridge, Massachusetts.
View all literature mentionsPublic image processing and analysis program for Macintosh.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
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