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NMR evaluation of total statin content and HMG-CoA reductase inhibition in red yeast rice (Monascus spp.) food supplements.

Dirk W Lachenmeier | Yulia B Monakhova | Thomas Kuballa | Sigrid Löbell-Behrends | Sibylle Maixner | Matthias Kohl-Himmelseher | Asja Waldner | Christian Steffen
Chinese medicine | 2012

Red yeast rice (i.e., rice fermented with Monascus spp.), as a food supplement, is claimed to be blood cholesterol-lowering. The red yeast rice constituent monacolin K, also known as lovastatin, is an inhibitor of the hydroxymethylglutaryl-CoA (HMG-CoA) reductase. This article aims to develop a sensitive nuclear magnetic resonance (NMR) method to determine the total statin content of red yeast rice products.

Pubmed ID: 22439629

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TopSpin (tool)

RRID:SCR_014227

Software package for NMR spectra acquisition, processing, and data analysis. Features include: deconvolution/spectrum simulation/iteration; comprehensive functionalities for processing, displaying and analyzing one and multi-dimensional spectra; and user customization. A full list of features is available on the website.

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