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The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes.

Minna-Liisa Änkö | Michaela Müller-McNicoll | Holger Brandl | Tomaz Curk | Crtomir Gorup | Ian Henry | Jernej Ule | Karla M Neugebauer
Genome biology | 2012

The SR proteins comprise a family of essential, structurally related RNA binding proteins. The complexity of their RNA targets and specificity of RNA recognition in vivo is not well understood. Here we use iCLIP to globally analyze and compare the RNA binding properties of two SR proteins, SRSF3 and SRSF4, in murine cells.

Pubmed ID: 22436691

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Associated grants

  • Agency: Wellcome Trust, United Kingdom
    Id: 089701
  • Agency: Medical Research Council, United Kingdom
    Id: MC_U105185858

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ArrayExpress (tool)

RRID:SCR_002964

International functional genomics data collection generated from microarray or next-generation sequencing (NGS) platforms. Repository of functional genomics data supporting publications. Provides genes expression data for reuse to the research community where they can be queried and downloaded. Integrated with the Gene Expression Atlas and the sequence databases at the European Bioinformatics Institute. Contains a subset of curated and re-annotated Archive data which can be queried for individual gene expression under different biological conditions across experiments. Data collected to MIAME and MINSEQE standards. Data are submitted by users or are imported directly from the NCBI Gene Expression Omnibus.

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Bowtie (tool)

RRID:SCR_005476

Software ultrafast memory efficient tool for aligning sequencing reads. Bowtie is short read aligner.

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